A Case of Ceftriaxone-Induced Acute Generalized Exanthematous Pustulosis/Generalized Pustular Psoriasis Overlap

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The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis.

BACKGROUND Acute generalized exanthematous pustulosis (AGEP) represents a severe, acute, pustular skin reaction that is most often induced by drugs. AGEP can be difficult to differentiate from generalized pustular psoriasis (GPP) both clinically and histopathologically. We present a systematic description of the histopathological spectrum of AGEP and GPP with a focus on discriminating features....

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Acute generalized exanthematous pustulosis induced by ceftriaxone use

Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous rash characterized by the abrupt onset of a generalized pustular rash often accompanied by fever. There is a history of drug use in 90% of the cases. Here we have reported a 15-year-old male patient with sickle cell anemia who developed AGEP after the use of ceftriaxone. Our patient was hospitalized because of vaso-occlusive ...

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Acute generalized exanthematous pustulosis x Von Zumbusch’s pustular psoriasis: A diagnostic challenge in a psoriatic patient*

Severe cutaneous drug reactions include a wide spectrum of clinical manifestations ranging from mild morbilliform cutaneous rash, to severe forms of hypersensitivity. Special attention is given in this report to the acute generalized exanthematous pustulosis (AGEP), induced in 90% of cases by the use of systemic drugs, especially aminopenicillins and macrolides. The incidence of the disease is ...

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Case Report A case of generalised pustular psoriasis mimicking acute generalised exanthematous pustulosis

Differentiating between acute generalised exanthematous pustulosis (AGEP) and generalised pustular psoriasis (GPP) is very challenging because of clinical and histopathological similarities. A 60-year-old woman presented with pustular eruption and fever. She had taken dapsone and zaltoprofen for five days. Laboratory findings revealed neutrophil dominant leucocytosis and histopathological findi...

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Immunohistochemical Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis

BACKGROUND Cutaneous pustular disorders include generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP). OBJECTIVE To identify differences between GPP and AGEP, here we immunohistochemically evaluated interleukin (IL)-36 and the IL-23/Th17 axis. METHODS This retrospective comparative immunohistochemical study was completed using 11 biopsies of 11 cases of ...

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ژورنال

عنوان ژورنال: Case Reports in Dermatology

سال: 2018

ISSN: 1662-6567

DOI: 10.1159/000488076